Buy Dalmane online, Buy Flurazepam online

Dalmane known as Flurazepam is a hypnotic agent used for the treatment of insomnia characterized by difficulty in falling asleep, frequent nocturnal awakenings, and/or early morning awakening.

Indications

Flurazepam can be used effectively in patients with recurring insomnia or poor sleeping habits, and in acute or chronic medical situations requiring restful sleep.

Sleep laboratory studies have objectively determined that Flurazepam/Dalmane is effective for at least 28 consecutive nights of drug administration. Since insomnia is often transient and intermittent, short-term use is usually enough.

Prolonged use of hypnotics is usually not indicated and should only be undertaken concomitantly with appropriate evaluation of the patient.

Therapeutic Class

Benzodiazepine hypnotics

Pharmacology

Flurazepam/Dalmane is a long-acting benzodiazepine which binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS, including the limbic system, reticular formation.

It enhances the inhibitory effect of GABA on neuronal excitability by increasing neuronal membrane permeability to Cl ions, thus resulting in hyperpolarisation and stabilisation.

Dosage & Administration

Oral-
Short-term management of insomnia

• Adult: 15-30 mg at night.

• Child: ≥15 yr 15 mg at night.

• Elderly: Max: 15 mg at night.

May be taken with or without food.

Interaction

May enhance CNS depressant effect with antidepressants, antipsychotics, general anaesth, hypnotics or sedatives, opioid analgesics. Flurazepam/Dalmane clearance may be reduced by cimetidine and may be increased by rifampicin.

Contraindications

Patient with pre-existing CNS depression or coma, resp depression, acute pulmonary insufficiency, myasthenia gravis, sleep apnoea, chronic psychosis or obsessional states. Pregnancy.

Side Effects

Dizziness or difficulty with coordination may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. To reduce the risk of dizziness or falling, get up slowly when rising from a sitting or lying position.

This medication may make you sleepy during the day. Tell your doctor if you have daytime drowsiness. Your dose may need to be adjusted.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: memory loss, mental/mood/behavior changes (such as new/worsening depression, abnormal thoughts, thoughts of suicide, hallucinations, confusion, agitation, aggressive behavior, anxiety).

Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake (“sleep-driving”). People have also sleepwalked, prepared/eaten food, made phone calls, or had sex while not fully awake. Often, these people do not remember these events. This problem can be dangerous to you or to others.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Pregnancy & Lactation

Category X: Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Precautions & Warnings

Patient with chronic pulmonary insufficiency, personality disorder, depression, resp disease, impaired gag reflex, history of alcohol or drug addiction. Renal and hepatic impairment. Children (<15 yr), elderly or debilitated patient. Lactation.

Overdose Effects

Symptoms: Mental confusion, somnolence, lethargy, dysarthria, impaired vision, dystonia to ataxia, unconsciousness, central resp and/or circulatory depression, coma.

Management: Symptomatic and supportive treatment. Induce vomiting or gastric lavage if taken within 1 hr. May admin activated charcoal to reduce absorption. Flumazenil may be used as an adjunct to proper management.

Storage Conditions

Store between 15-30°C.