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Dapagliflozin is known as a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It lowers blood sugar levels in people with diabetes.

It does this by helping remove excess sugar from your body through your pee.

Indications

Dapagliflozin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus Farxiga (dapagliflozin) Online

Pharmacology

Dapagliflozin is a highly potent, selective, and reversible inhibitor of sodium-glucose cotransporter 2 (SGLT2) that improves glycemic control in patients with type 2 diabetes mellitus by reducing renal glucose reabsorption leading to urinary excretion of excess glucose (glucuresis).

Dosage & Administration

5 mg orally once a day. May increase to 10 mg orally once a day in patients tolerating therapy with 5 mg and requiring additional glycemic control

Interaction

Hypoglycemia may occur with concomitant use with insulin & insulin secretagogues eg sulfonylureas. Decrease in Cmax & AUC with rifampin. Increase in Cmax & AUC with mefenamic acid.

Increased thiazide & loop diuretic effects; may increase risk of dehydration & hypotension. Pioglitazone. Farxiga (dapagliflozin) Online

Contraindications

Hypersensitivity to dapagliflozin propanediol or to any of the excipients. Moderate to severe renal impairment; end-stage renal disease; active bladder cancer. Pregnancy (2nd & 3rd trimester) & lactation.

Side Effects

Renal impairment, Female genital mycotic infections, Urinary tract infection, Increased urination, Male genital mycotic infections, Dyslipidemia, Constipation, Discomfort with urination, Extremity pain, Volume depletion, Hypersensitivity Farxiga (dapagliflozin) Online

Pregnancy & Lactation

Pregnancy Category-C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may

warrant use of the drug in pregnant women despite potential risks Farxiga (dapagliflozin) Online

Precautions & Warnings

CV disease, history of hypotension, UTI, Children, Elderly. Unknown whether distributed in human breast milk; breastfeeding women should discontinue dapagliflozin or nursing considering the importance of the drug to the mother

Use in Special Populations

Renal Impairment: No dosage adjustment is indicated based on renal function. The efficacy is dependent on renal function. Farxiga (dapagliflozin) Online

lt is not recommended for use in patients with moderate to severe renal impairment (patients with CrCI <60 mL/min or eGFR <60 mL/min/1.73 m²).

Therapeutic Class

Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors