Buy Baclofen online, Buy Lioresal online.

Baclofen | Lioresal is used to treat muscle pain, spasms, and stiffness in people with multiple sclerosis or spinal cord injury or disease. 

Indications

Baclofen is indicated in-

Spasm, Reflex muscle contractions, Indirect effects of treatment with Baclofen include, improved sleep patterns, improvement in bladder and sphincter function and helps in the prevention and healing of decubitus ulcers, Spasticity resulting from multiple sclerosis. Spinal cord injuries and other spinal cord

 diseases. Muscle spasm of cerebral origin especially infantile cerebral palsy. Cerebrovascular accidents or neoplastic or degenerative brain disease. Tension-type headache.

Therapeutic Class

Centrally acting Skeletal Muscle Relaxants

Description

Baclofen is a centrally acting skeletal muscle relaxant and an antispastic agent with a spinal site of action.

Pharmacology

Baclofen is an effective muscle relaxant and antispastic agent with a spinal site of action. Its mode of action is not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating the GABA_B-receptors, which inhibits the release of glutamate and aspartate.

It may also act at intraspinal sites producing CNS depression. Neuromuscular transmission is not affected by Baclofen. Baclofen also exerts an antinoceptive effect but the clinical significance of this is unknown.

Dosage & Administration

Baclofen should be taken during meals with a little liquid. Baclofen should be given in divided doses preferably 3 times daily for adults and 4 times daily for children. The lowest dose compatible with an optimal response is recommended.

If benefits are not evident after a 6 to 8-week trial period, patients should be slowly withdrawn from the drug.

Interaction

• Increased sedation may occur if Baclofen is taken with agents acting on the central nervous system, alcohol or synthetic opiates. The risk of respiratory depression is also increased.

Combined treatment with Lioresal and antihypertensives is likely to increase the fall in blood pressure; therefore, the dosage of antihypertensive medication should be adjusted accordingly.

The concomitant administration of Baclofen and tricyclic antidepressants may potentiate the pharmacological effects of Baclofen resulting in pronounced muscular hypotonia.

In patients with Parkinsons disease receiving treatment with Lioresal and levodopa and carbidopa, there have been several reports of mental confusion, hallucinations, headaches, nausea and agitation.

The concurrent use of MAO inhibitors and Lioresal may result in increased CNS depressant effects. Caution is advised and the dosage of one or both agents should be adjusted accordingly.

Caution should be exercised when administering Baclofen and magnesium sulphate or other neuromuscular blocking agents since a synergistic effect may theoretically occur.

Contraindications

Baclofen is contraindicated in patients with hypersensitivity to any component of this product.

Side Effects

The most common adverse reactions associated with Lioresal are transient drowsiness, daytime sedation, dizziness, weakness and fatigue.

• Central Nervous System: Headache (<10%), insomnia (<10%), and rarely, euphoria, excitement, depression, confusion, hallucinations, paraesthesia, nightmares, muscle pain, tinnitus, slurred speech,

co-ordination disorder, tremor, rigidity, dystonia, ataxia, blurred vision, nystagmus, strabismus, miosis, mydriasis, diplopia, dysarthria, epileptic seizures, respiratory depression.

• Cardiovascular: Hypotension (<10%), rare instances of dyspnoea, palpitation, chest pain, syncope.

• Gastrointestinal: Nausea (approximately 10%), constipation (<10%) and rarely, dry mouth, anorexia, taste disorder, abdominal pain, vomiting, diarrhoea and positive test for occult blood in stool.

• Genitourinary: Urinary frequency (<10%) and rarely, enuresis, urinary retention, dysuria, impotence, inability to ejaculate, nocturia, haematuria.

Pregnancy & Lactation

Pregnancy category B3. Safe use of Lioresal during pregnancy has not been established. Baclofen crosses the placental barrier. Lioresal should only be administered to pregnant women when in the judgement of the physician concludes that the potential benefits outweigh the possible hazards.

 Baclofen is excreted in breast milk however evidence to date suggests that the quantities are so small that no undesirable effects on the infant would be expected.

Precautions & Warnings

• Lower doses (approximately 5 mg per day) should be used for patients with impaired renal function or those undergoing chronic haemodialysis.

• Patients suffering not only from spasticity but also from psychotic disorders, schizophrenia, depressive or manic disorders or confusional states should be treated cautiously and closely monitored as exacerbations of these disorders may occur.

• In patients with epilepsy and muscle spasticity, Lioresal may be used under appropriate supervision and provided that adequate anticonvulsive therapy is continued. Lowering of the convulsion threshold may occur and seizures have been reported after the cessation of Lioresal therapy or with overdose.

Overdose Effects

Symptoms of a Lioresal overdose include vomiting, weakness, drowsiness, slow breathing,seizures, unusual pupil size, and coma.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.