Buy Baricitinib 4 mg online, Buy Olumiant online

Baricinix 4 is the alternative & generic version of Olumiant  by Eli Lilly and Company. Baricinix is manufactured by Beacon Pharmaceuticals Bangladesh which is the biggest pharmaceutical company in Bangladesh.

Baricinix (Olumiant) Baricitinib by Beacon Pharmaceuticalsis is used to treat moderate to severe active rheumatoid arthritis in adult patients.

Baricitinib is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs. Baricitinib may be used as monotherapy or in combination with Methotrexate.

Therapeutic Class

Immunosuppressant

Pharmacology

Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function.

Within the signaling pathway, JAKs phosphorylate and activate Signal Transducers and Activators of Transcription (STATs) which modulate intracellular activity including gene expression. Baricitinib /olumiant modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs.

Dosage & Administration

The recommended dose of Baricitinib / olumiantis 2 mg once daily. Baricitinib may be used as monotherapy or in combination with Methotrexate or other DMARDs.

Interaction

The recommended dose of Baricitinib in patients taking strong Organic Anion Transporter 3 (OAT3) inhibitors (e.g., probenecid) is 1 mg once daily

Contraindications

Anemia: Avoid initiation or interrupt Baricitinib in patients with hemoglobin less than 8 g/dL.

Lymphopenia: Avoid initiation or interrupt Baricitinib /olumiant in patients with an Absolute Lymphocyte Count less than 500 cells/mm3.

Neutropenia: Avoid initiation or interrupt Baricitinib /olumiant in patients with an Absolute Neutrophil Count less than 1000 cells/mm3.

Side Effects

People using this medication may have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor right away if you have any serious side effects, including: signs of anemia (such as unusual tiredness, pale skin, fast heartbeat), signs of liver disease (such as nausea/vomiting that doesn’t stop, loss of appetite

stomach/abdominal pain, yellowing eyes/skin, dark urine), signs of a serious tear in the stomach or intestinal wall (such as severe stomach/abdominal pain that doesn’t go away, fever, severe dizziness, fainting, severe nausea/vomiting).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Pregnancy & Lactation

It is not known if Baricitinib /olumiant will harm an unborn baby. Because of the potential for serious adverse reactions in nursing infants, advice a Baricitinib treated woman not to breastfeed.

Precautions & Warnings

Serious Infections: Avoid use of Baricitinib /olumiant in patients with active, serious infection, including localized infections. If a serious infection develops, interrupt Baricitinib therapy until the infection is controlled. Do not give Baricitinib /olumiant to patients with active tuberculosis.

Thrombosis: Use with caution in patients who may be at increased risk.

Gastrointestinal Perforations: Use with caution in patients who may be at increased risk.

Laboratory Assessment: Recommended due to potential changes in lymphocytes, neutrophils, hemoglobin, liver enzymes, and lipids.

Vaccinations: Avoid use of Baricitinib /olumiant with live vaccines

Use in Special Populations

Moderate Renal Impairment: Reduce dose to 1 mg once daily.

Overdose Effects

In case of an overdose, it is recommended that the patient should be monitored for signs and symptoms of adverse reactions. Patients who develop adverse reactions should receive appropriate treatment.

Storage Conditions

Store below 30°C. Protect from light & moisture. Keep all medicines out of the reach of children.